Microsatellite instability derived JAK1 frameshift mutations are associated with tumor immune evasion in endometrioid endometrial cancer

JAK1 frameshift mutations may promote cancer cell immune evasion by impeding upregulation of the antigen presentation pathway in microsatellite unstable endometrial cancers (ECs). This study investigated the JAK1 mutation frequency, its functional implication in immune evasion and its prognostic sig...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Stelloo, Ellen, Versluis, Marco A., Nijman, Hans W., de Bruyn, Marco, Plat, Annechien, Osse, Elisabeth M., van Dijk, Reinhardt H., Nout, Remi A., Creutzberg, Carien L., de Bock, Geertruida H., Smit, Vincent T., Bosse, Tjalling, Hollema, Harry
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2016
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129978/
https://ncbi.nlm.nih.gov/pubmed/27213585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9414
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