Targeting Mutant Fibroblast Growth Factor Receptors in Cancer

Por Greulich, Heidi, Pollock, Pamela M.
Publicado em 2011

Lineage specific biomarkers predict response to FGFR inhibition

Por Loch, David C., Pollock, Pamela M.
Publicado no Cancer Discov (2012)

Fibroblast Growth Factor Receptor 2 Isoforms Detected via Novel RNA ISH as Predictive Biomarkers for Progestin Therapy in Atypical Hyperplasia and Low-Grade Endometrial Cancer

Por Sengal, Asmerom T., Smith, Deborah, Rogers, Rebecca, Snell, Cameron E., Williams, Elizabeth D., Pollock, Pamela M.
Publicado no Cancers (Basel) (2021)

Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk

Por Zhao, Zhen Zhen, Pollock, Pamela M., Thomas, Shane, Treloar, Susan A., Nyholt, Dale R., Montgomery, Grant W.
Publicado em 2008

Endometrial cancer cells exhibit high expression of p110β and its selective inhibition induces variable responses on PI3K signaling, cell survival and proliferation

Por Karlsson, Thomas, Krakstad, Camilla, Tangen, Ingvild Løberg, Hoivik, Erling A., Pollock, Pamela M., Salvesen, Helga B., Lewis, Aurélia E.
Publicado no Oncotarget (2016)

Sensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant BRAF and wildtype PTEN status

Por Byron, Sara A, Loch, David C, Wellens, Candice L, Wortmann, Andreas, Wu, Jiayi, Wang, John, Nomoto, Kenichi, Pollock, Pamela M
Publicado em 2012

Cellular Settings Mediating Src Substrate Switching between Focal Adhesion Kinase Tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) Tyrosine 734

Por Wortmann, Andreas, He, Yaowu, Christensen, Melinda E., Linn, MayLa, Lumley, John W., Pollock, Pamela M., Waterhouse, Nigel J., Hooper, John D.
Publicado em 2011

FGFR2 Point Mutations in 466 Endometrioid Endometrial Tumors: Relationship with MSI, KRAS, PIK3CA, CTNNB1 Mutations and Clinicopathological Features

Por Byron, Sara A., Gartside, Michael, Powell, Matthew A., Wellens, Candice L., Gao, Feng, Mutch, David G., Goodfellow, Paul J., Pollock, Pamela M.
Publicado em 2012

Correction: FGFR2 Point Mutations in 466 Endometrioid Endometrial Tumors: Relationship with MSI, KRAS, PIK3CA, CTNNB1 Mutations and Clinicopathological Features

Por Byron, Sara A., Gartside, Michael, Powell, Matthew A., Wellens, Candice L., Gao, Feng, Mutch, David G., Goodfellow, Paul J., Pollock, Pamela M.
Publicado em 2012

The ‘melanoma-enriched’ microRNA miR-4731-5p acts as a tumour suppressor

Por Stark, Mitchell S., Tom, Lisa N., Boyle, Glen M., Bonazzi, Vanessa F., Soyer, H. Peter, Herington, Adrian C., Pollock, Pamela M., Hayward, Nicholas K.
Publicado no Oncotarget (2016)

Humanized bone facilitates prostate cancer metastasis and recapitulates therapeutic effects of zoledronic acid in vivo

Por Landgraf, Marietta, Lahr, Christoph A., Sanchez-Herrero, Alvaro, Meinert, Christoph, Shokoohmand, Ali, Pollock, Pamela M., Hutmacher, Dietmar W., Shafiee, Abbas, McGovern, Jacqui A.
Publicado no Bone Res (2019)

Correction: Humanized bone facilitates prostate cancer metastasis and recapitulates therapeutic effects of Zoledronic acid in vivo

Por Landgraf, Marietta, Lahr, Christoph A., Sanchez-Herrero, Alvaro, Meinert, Christoph, Shokoohmand, Ali, Pollock, Pamela M., Hutmacher, Dietmar W., Shafiee, Abbas, McGovern, Jacqui A.
Publicado no Bone Res (2020)

A crystallographic snapshot of tyrosine trans-phosphorylation in action

Por Chen, Huaibin, Xu, Chong-Feng, Ma, Jinghong, Eliseenkova, Anna V., Li, Wanqing, Pollock, Pamela M., Pitteloud, Nelly, Miller, W. Todd, Neubert, Thomas A., Mohammadi, Moosa
Publicado em 2008

The N550K/H Mutations in FGFR2 Confer Differential Resistance to PD173074, Dovitinib, and Ponatinib ATP-Competitive Inhibitors

Por Byron, Sara A, Chen, Huaibin, Wortmann, Andreas, Loch, David, Gartside, Michael G, Dehkhoda, Farhad, Blais, Steven P, Neubert, Thomas A, Mohammadi, Moosa, Pollock, Pamela M
Publicado em 2013

Bcl‐2 inhibitors enhance FGFR inhibitor‐induced mitochondrial‐dependent cell death in FGFR2‐mutant endometrial cancer

Por Packer, Leisl M., Stehbens, Samantha J., Bonazzi, Vanessa F., Gunter, Jennifer H., Ju, Robert J., Ward, Micheal, Gartside, Michael G., Byron, Sara A., Pollock, Pamela M.
Publicado no Mol Oncol (2019)

Identifying Therapies to Combat Epithelial Mesenchymal Plasticity-Associated Chemoresistance to Conventional Breast Cancer Therapies Using An shRNA Library Screen

Por Bhatia, Sugandha, Blick, Tony, Pinto, Cletus, Waltham, Mark, Monkman, James, Ivanova, Ekaterina, Pollock, Pamela M., Nagaraj, Shivashankar H., Wiegmans, Adrian P., Haviv, Izhak, Simpson, Kaylene J., Thompson, Erik W.
Publicado no Cancers (Basel) (2020)

miR-514a regulates the tumour suppressor NF1 and modulates BRAFi sensitivity in melanoma

Por Stark, Mitchell S., Bonazzi, Vanessa F., Boyle, Glen M., Palmer, Jane M., Symmons, Judith, Lanagan, Catherine M., Schmidt, Christopher W., Herington, Adrian C., Ballotti, Robert, Pollock, Pamela M., Hayward, Nicholas K.
Publicado no Oncotarget (2015)

Homodimerization Controls the Fibroblast Growth Factor 9 Subfamily's Receptor Binding and Heparan Sulfate-Dependent Diffusion in the Extracellular Matrix

Por Kalinina, Juliya, Byron, Sara A., Makarenkova, Helen P., Olsen, Shaun K., Eliseenkova, Anna V., Larochelle, William J., Dhanabal, Mohanraj, Blais, Steven, Ornitz, David M., Day, Loren A., Neubert, Thomas A., Pollock, Pamela M., Mohammadi, Moosa
Publicado em 2009

A Phase II Trial of Brivanib in Recurrent or Persistent Endometrial Cancer: An NRG Oncology/Gynecologic Oncology Group Study

Por Powell, Matthew A., Sill, Michael W., Goodfellow, Paul J., Benbrook, Doris M., Lankes, Heather A., Leslie, Kimberly K., Jeske, Yvette, Mannel, Robert S., Spillman, Monique A, Lee, Paula S., Hoffman, James S., McMeekin, D. Scott, Pollock, Pamela M.
Publicado no Gynecol Oncol (2014)

p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation

Por Terzian, Tamara, Torchia, Enrique C., Dai, Daisy, Robinson, Steven E., Murao, Kazutoshi, Stiegmann, Regan A., Gonzalez, Victoria, Boyle, Glen M., Powell, Marianne B., Pollock, Pamela M., Lozano, Guillermina, Robinson, William A., Roop, Dennis R., Box, Neil F.
Publicado em 2010