A crystallographic snapshot of tyrosine trans-phosphorylation in action

Tyrosine trans-phosphorylation is a key event in receptor tyrosine kinase signaling, yet, the structural basis for this process has eluded definition. Here, we present the crystal structure of the FGF receptor 2 kinases caught in the act of trans-phosphorylation of Y769, the major C-terminal phospho...

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Dettagli Bibliografici
Autori principali: Chen, Huaibin, Xu, Chong-Feng, Ma, Jinghong, Eliseenkova, Anna V., Li, Wanqing, Pollock, Pamela M., Pitteloud, Nelly, Miller, W. Todd, Neubert, Thomas A., Mohammadi, Moosa
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605006/
https://ncbi.nlm.nih.gov/pubmed/19060208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807752105
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