Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation

A long-standing mystery shrouds the mechanism by which catalytically repressed receptor tyrosine kinase domains accomplish transphosphorylation of activation loop (A-loop) tyrosines. Here we show that this reaction proceeds via an asymmetric complex that is thermodynamically disadvantaged because of...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Nat Chem Biol
Autores principales: Chen, Lingfeng, Marsiglia, William M., Chen, Huaibin, Katigbak, Joseph, Erdjument-Bromage, Hediye, Kemble, David J., Fu, Lili, Ma, Jinghong, Sun, Gongqin, Zhang, Yingkai, Liang, Guang, Neubert, Thomas A., Li, Xiaokun, Traaseth, Nathaniel J., Mohammadi, Moosa
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7040854/
https://ncbi.nlm.nih.gov/pubmed/31959966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0455-7
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares