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A ‘Molecular Brake’ in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine Kinases
Activating mutations in the tyrosine kinase domain of receptor tyrosine kinases (RTKs) cause cancer and skeletal disorders. Comparison of the crystal structures of unphosphorylated and phosphorylated wild-type FGFR2 kinase domains with those of seven unphosphorylated pathogenic mutants reveals an au...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2094128/ https://ncbi.nlm.nih.gov/pubmed/17803937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.06.028 |
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