Homodimerization Controls the Fibroblast Growth Factor 9 Subfamily's Receptor Binding and Heparan Sulfate-Dependent Diffusion in the Extracellular Matrix

Uncontrolled fibroblast growth factor (FGF) signaling can lead to human diseases, necessitating multiple layers of self-regulatory control mechanisms to keep its activity in check. Herein, we demonstrate that FGF9 and FGF20 ligands undergo a reversible homodimerization, occluding their key receptor...

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Bibliografiske detaljer
Main Authors: Kalinina, Juliya, Byron, Sara A., Makarenkova, Helen P., Olsen, Shaun K., Eliseenkova, Anna V., Larochelle, William J., Dhanabal, Mohanraj, Blais, Steven, Ornitz, David M., Day, Loren A., Neubert, Thomas A., Pollock, Pamela M., Mohammadi, Moosa
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725704/
https://ncbi.nlm.nih.gov/pubmed/19564416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01780-08
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