Homodimerization Controls the Fibroblast Growth Factor 9 Subfamily's Receptor Binding and Heparan Sulfate-Dependent Diffusion in the Extracellular Matrix

Uncontrolled fibroblast growth factor (FGF) signaling can lead to human diseases, necessitating multiple layers of self-regulatory control mechanisms to keep its activity in check. Herein, we demonstrate that FGF9 and FGF20 ligands undergo a reversible homodimerization, occluding their key receptor...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Kalinina, Juliya, Byron, Sara A., Makarenkova, Helen P., Olsen, Shaun K., Eliseenkova, Anna V., Larochelle, William J., Dhanabal, Mohanraj, Blais, Steven, Ornitz, David M., Day, Loren A., Neubert, Thomas A., Pollock, Pamela M., Mohammadi, Moosa
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2009
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725704/
https://ncbi.nlm.nih.gov/pubmed/19564416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01780-08
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky