Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization

The epithelial FGF9 subfamily specifically binds and activates the mesenchymal ‘c’ splice isoform of FGF receptor 1–3 to regulate organogenesis and tissue homeostasis. The unique N and C-termini of FGF9 subfamily ligands mediate a reversible homodimerization that occludes major receptor binding site...

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Bibliografiske detaljer
Udgivet i:Structure
Main Authors: Liu, Yang, Ma, Jinghong, Beenken, Andrew, Srinivasan, Lakshmi, Eliseenkova, Anna V., Mohammadi, Moosa
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587394/
https://ncbi.nlm.nih.gov/pubmed/28757146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.06.016
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