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Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization
The epithelial FGF9 subfamily specifically binds and activates the mesenchymal ‘c’ splice isoform of FGF receptor 1–3 to regulate organogenesis and tissue homeostasis. The unique N and C-termini of FGF9 subfamily ligands mediate a reversible homodimerization that occludes major receptor binding site...
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| Publicado no: | Structure |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5587394/ https://ncbi.nlm.nih.gov/pubmed/28757146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.06.016 |
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