Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members

Unique among fibroblast growth factors (FGFs), FGF19, -21, and -23 act in an endocrine fashion to regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis. These FGFs require the presence of Klotho/βKlotho in their target tissues. Here, we present the crystal structures of FG...

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Main Authors: Goetz, Regina, Beenken, Andrew, Ibrahimi, Omar A., Kalinina, Juliya, Olsen, Shaun K., Eliseenkova, Anna V., Xu, ChongFeng, Neubert, Thomas A., Zhang, Fuming, Linhardt, Robert J., Yu, Xijie, White, Kenneth E., Inagaki, Takeshi, Kliewer, Steven A., Yamamoto, Masaya, Kurosu, Hiroshi, Ogawa, Yasushi, Kuro-o, Makoto, Lanske, Beate, Razzaque, Mohammed S., Mohammadi, Moosa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899957/
https://ncbi.nlm.nih.gov/pubmed/17339340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02249-06
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