Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members

Unique among fibroblast growth factors (FGFs), FGF19, -21, and -23 act in an endocrine fashion to regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis. These FGFs require the presence of Klotho/βKlotho in their target tissues. Here, we present the crystal structures of FG...

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Egile Nagusiak: Goetz, Regina, Beenken, Andrew, Ibrahimi, Omar A., Kalinina, Juliya, Olsen, Shaun K., Eliseenkova, Anna V., Xu, ChongFeng, Neubert, Thomas A., Zhang, Fuming, Linhardt, Robert J., Yu, Xijie, White, Kenneth E., Inagaki, Takeshi, Kliewer, Steven A., Yamamoto, Masaya, Kurosu, Hiroshi, Ogawa, Yasushi, Kuro-o, Makoto, Lanske, Beate, Razzaque, Mohammed S., Mohammadi, Moosa
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2007
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Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899957/
https://ncbi.nlm.nih.gov/pubmed/17339340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02249-06
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