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p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation
p53 is the central member of a critical tumor suppressor pathway in virtually all tumor types, where it is silenced mainly by missense mutations. In melanoma, p53 predominantly remains wild type, thus its role has been neglected. To study the effect of p53 on melanocyte function and melanomagenesis,...
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Asıl Yazarlar: | , , , , , , , , , , , , , |
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Materyal Türü: | Artigo |
Dil: | Inglês |
Baskı/Yayın Bilgisi: |
2010
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Konular: | |
Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137930/ https://ncbi.nlm.nih.gov/pubmed/20849464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1755-148X.2010.00773.x |
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