p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation

p53 is the central member of a critical tumor suppressor pathway in virtually all tumor types, where it is silenced mainly by missense mutations. In melanoma, p53 predominantly remains wild type, thus its role has been neglected. To study the effect of p53 on melanocyte function and melanomagenesis,...

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Bibliografiske detaljer
Main Authors: Terzian, Tamara, Torchia, Enrique C., Dai, Daisy, Robinson, Steven E., Murao, Kazutoshi, Stiegmann, Regan A., Gonzalez, Victoria, Boyle, Glen M., Powell, Marianne B., Pollock, Pamela M., Lozano, Guillermina, Robinson, William A., Roop, Dennis R., Box, Neil F.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137930/
https://ncbi.nlm.nih.gov/pubmed/20849464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1755-148X.2010.00773.x
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