Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response

Genomic instability, which is a hallmark of cancer, is generally thought to occur in the middle to late stages of tumourigenesis, following the acquisition of permissive molecular aberrations such as TP53 mutation or whole genome doubling. Tumours with somatic POLE exonuclease domain mutations are n...

Szczegółowa specyfikacja

Zapisane w:
Opis bibliograficzny
Wydane w:J Pathol
Główni autorzy: Temko, Daniel, Van Gool, Inge C, Rayner, Emily, Glaire, Mark, Makino, Seiko, Brown, Matthew, Chegwidden, Laura, Palles, Claire, Depreeuw, Jeroen, Beggs, Andrew, Stathopoulou, Chaido, Mason, John, Baker, Ann‐Marie, Williams, Marc, Cerundolo, Vincenzo, Rei, Margarida, Taylor, Jenny C, Schuh, Anna, Ahmed, Ahmed, Amant, Frédéric, Lambrechts, Diether, Smit, Vincent THBM, Bosse, Tjalling, Graham, Trevor A, Church, David N, Tomlinson, Ian
Format: Artigo
Język:Inglês
Wydane: John Wiley & Sons, Ltd 2018
Hasła przedmiotowe:
Original Papers
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6032922/
https://ncbi.nlm.nih.gov/pubmed/29604063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5081
Etykiety: Dodaj etykietę
Nie ma etykietki, Dołącz pierwszą etykiete!

Podobne zapisy