Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

Maintenance of genomic stability depends on the DNA damage response, an extensive signaling network that is activated by DNA lesions such as double-strand breaks (DSBs). The primary activator of the mammalian DSB response is the nuclear protein kinase ataxia–telangiectasia, mutated (ATM), which phos...

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Bibliographische Detailangaben
Hauptverfasser: Pereg, Yaron, Shkedy, Dganit, de Graaf, Petra, Meulmeester, Erik, Edelson-Averbukh, Marina, Salek, Mogjiborahman, Biton, Sharon, Teunisse, Amina F. A. S., Lehmann, Wolf D., Jochemsen, Aart G., Shiloh, Yosef
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC555986/
https://ncbi.nlm.nih.gov/pubmed/15788536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408595102
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