Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

The p53 tumor-suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. This process is associated with posttranslational modifications of p53, some of which are mediated by the ATM protein kinase. However, these modifications alone...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Khosravi, Rami, Maya, Ruth, Gottlieb, Tanya, Oren, Moshe, Shiloh, Yosef, Shkedy, Dganit
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24757/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10611322/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.26.14973
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