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P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

The INK4a-ARF locus encodes two distinct tumor suppressors, p16(INK4a) and p19(ARF). Whereas p16(INK4a) restrains cell growth through preventing phosphorylation of the retinoblastoma protein, p19(ARF) acts by attenuating Mdm2-mediated degradation of p53, thereby stabilizing p53. Recent data indicate...

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Detalles Bibliográficos
Main Authors: Tao, Weikang, Levine, Arnold J.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 1999
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC22020/
https://ncbi.nlm.nih.gov/pubmed/10359817
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