P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2
The INK4a-ARF locus encodes two distinct tumor suppressors, p16(INK4a) and p19(ARF). Whereas p16(INK4a) restrains cell growth through preventing phosphorylation of the retinoblastoma protein, p19(ARF) acts by attenuating Mdm2-mediated degradation of p53, thereby stabilizing p53. Recent data indicate...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22020/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10359817/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.12.6937 |
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