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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

The p53 tumor-suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. This process is associated with posttranslational modifications of p53, some of which are mediated by the ATM protein kinase. However, these modifications alone...

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Autores principales: Khosravi, Rami, Maya, Ruth, Gottlieb, Tanya, Oren, Moshe, Shiloh, Yosef, Shkedy, Dganit
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 1999
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC24757/
https://ncbi.nlm.nih.gov/pubmed/10611322
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