Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study

The intracellular activity of the p53 tumor suppressor protein is regulated through a feedback loop involving its transcriptional target, mdm2. We present a simple mathematical model suggesting that, under certain circumstances, oscillations in p53 and Mdm2 protein levels can emerge in response to a...

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Podrobná bibliografie

Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Lev Bar-Or, Ruth, Maya, Ruth, Segel, Lee A., Alon, Uri, Levine, Arnold J., Oren, Moshe
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 2000
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17186/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11016968/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.210171597
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