Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making

PURPOSE: A long natural history and a predominant osseous pattern of metastatic spread are impediments to the adoption of precision medicine in patients with prostate cancer. To establish the feasibility of clinical genomic profiling in this disease, we performed targeted deep sequencing of tumor an...

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Publicado en:JCO Precis Oncol
Autores principales: Abida, Wassim, Armenia, Joshua, Gopalan, Anuradha, Brennan, Ryan, Walsh, Michael, Barron, David, Danila, Daniel, Rathkopf, Dana, Morris, Michael, Slovin, Susan, McLaughlin, Brigit, Curtis, Kristen, Hyman, David M., Durack, Jeremy C., Solomon, Stephen B., Arcila, Maria E., Zehir, Ahmet, Syed, Aijazuddin, Gao, Jianjiong, Chakravarty, Debyani, Vargas, Hebert Alberto, Robson, Mark E., Vijai, Joseph, Offit, Kenneth, Donoghue, Mark T.A., Abeshouse, Adam A., Kundra, Ritika, Heins, Zachary J., Penson, Alexander V., Harris, Christopher, Taylor, Barry S., Ladanyi, Marc, Mandelker, Diana, Zhang, Liying, Reuter, Victor E., Kantoff, Philip W., Solit, David B., Berger, Michael F., Sawyers, Charles L., Schultz, Nikolaus, Scher, Howard I.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Clinical Oncology 2017
Materias:
Original Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558263/
https://ncbi.nlm.nih.gov/pubmed/28825054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.17.00029
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