Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making

PURPOSE: A long natural history and a predominant osseous pattern of metastatic spread are impediments to the adoption of precision medicine in patients with prostate cancer. To establish the feasibility of clinical genomic profiling in this disease, we performed targeted deep sequencing of tumor an...

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Bibliografiske detaljer
Udgivet i:JCO Precis Oncol
Main Authors: Abida, Wassim, Armenia, Joshua, Gopalan, Anuradha, Brennan, Ryan, Walsh, Michael, Barron, David, Danila, Daniel, Rathkopf, Dana, Morris, Michael, Slovin, Susan, McLaughlin, Brigit, Curtis, Kristen, Hyman, David M., Durack, Jeremy C., Solomon, Stephen B., Arcila, Maria E., Zehir, Ahmet, Syed, Aijazuddin, Gao, Jianjiong, Chakravarty, Debyani, Vargas, Hebert Alberto, Robson, Mark E., Vijai, Joseph, Offit, Kenneth, Donoghue, Mark T.A., Abeshouse, Adam A., Kundra, Ritika, Heins, Zachary J., Penson, Alexander V., Harris, Christopher, Taylor, Barry S., Ladanyi, Marc, Mandelker, Diana, Zhang, Liying, Reuter, Victor E., Kantoff, Philip W., Solit, David B., Berger, Michael F., Sawyers, Charles L., Schultz, Nikolaus, Scher, Howard I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2017
Fag:
Original Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558263/
https://ncbi.nlm.nih.gov/pubmed/28825054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.17.00029
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