Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making

PURPOSE: A long natural history and a predominant osseous pattern of metastatic spread are impediments to the adoption of precision medicine in patients with prostate cancer. To establish the feasibility of clinical genomic profiling in this disease, we performed targeted deep sequencing of tumor an...

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Vydáno v:JCO Precis Oncol
Hlavní autoři: Abida, Wassim, Armenia, Joshua, Gopalan, Anuradha, Brennan, Ryan, Walsh, Michael, Barron, David, Danila, Daniel, Rathkopf, Dana, Morris, Michael, Slovin, Susan, McLaughlin, Brigit, Curtis, Kristen, Hyman, David M., Durack, Jeremy C., Solomon, Stephen B., Arcila, Maria E., Zehir, Ahmet, Syed, Aijazuddin, Gao, Jianjiong, Chakravarty, Debyani, Vargas, Hebert Alberto, Robson, Mark E., Vijai, Joseph, Offit, Kenneth, Donoghue, Mark T.A., Abeshouse, Adam A., Kundra, Ritika, Heins, Zachary J., Penson, Alexander V., Harris, Christopher, Taylor, Barry S., Ladanyi, Marc, Mandelker, Diana, Zhang, Liying, Reuter, Victor E., Kantoff, Philip W., Solit, David B., Berger, Michael F., Sawyers, Charles L., Schultz, Nikolaus, Scher, Howard I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2017
Témata:
Original Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558263/
https://ncbi.nlm.nih.gov/pubmed/28825054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.17.00029
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