Therapy-related clonal hematopoiesis in patients with non-hematologic cancers is common and impacts clinical outcome

Clonal hematopoiesis (CH), as evidenced by recurrent somatic mutations in leukemia-associated genes, commonly occurs among aging human hematopoietic stem cells. We analyzed deep coverage, targeted next-generation sequencing (NGS) data of paired tumor and blood samples from 8,810 individuals to asses...

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Udgivet i:Cell Stem Cell
Main Authors: Coombs, Catherine C., Zehir, Ahmet, Devlin, Sean M., Kishtagari, Ashwin, Syed, Aijazuddin, Jonsson, Philip, Hyman, David M., Solit, David B., Robson, Mark E., Baselga, José, Arcila, Maria E., Ladanyi, Marc, Tallman, Martin S., Levine, Ross L., Berger, Michael F.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591073/
https://ncbi.nlm.nih.gov/pubmed/28803919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.07.010
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