Therapy-related clonal hematopoiesis in patients with non-hematologic cancers is common and impacts clinical outcome

Clonal hematopoiesis (CH), as evidenced by recurrent somatic mutations in leukemia-associated genes, commonly occurs among aging human hematopoietic stem cells. We analyzed deep coverage, targeted next-generation sequencing (NGS) data of paired tumor and blood samples from 8,810 individuals to asses...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Cell Stem Cell
Autori principali: Coombs, Catherine C., Zehir, Ahmet, Devlin, Sean M., Kishtagari, Ashwin, Syed, Aijazuddin, Jonsson, Philip, Hyman, David M., Solit, David B., Robson, Mark E., Baselga, José, Arcila, Maria E., Ladanyi, Marc, Tallman, Martin S., Levine, Ross L., Berger, Michael F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591073/
https://ncbi.nlm.nih.gov/pubmed/28803919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.07.010
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi