Therapy-related clonal hematopoiesis in patients with non-hematologic cancers is common and impacts clinical outcome

Clonal hematopoiesis (CH), as evidenced by recurrent somatic mutations in leukemia-associated genes, commonly occurs among aging human hematopoietic stem cells. We analyzed deep coverage, targeted next-generation sequencing (NGS) data of paired tumor and blood samples from 8,810 individuals to asses...

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Bibliographic Details
Published in:Cell Stem Cell
Main Authors: Coombs, Catherine C., Zehir, Ahmet, Devlin, Sean M., Kishtagari, Ashwin, Syed, Aijazuddin, Jonsson, Philip, Hyman, David M., Solit, David B., Robson, Mark E., Baselga, José, Arcila, Maria E., Ladanyi, Marc, Tallman, Martin S., Levine, Ross L., Berger, Michael F.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591073/
https://ncbi.nlm.nih.gov/pubmed/28803919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.07.010
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