Cancer therapy shapes the fitness landscape of clonal hematopoiesis

Acquired mutations are pervasive across normal tissues. However, our understanding of the processes that drive transformation of certain clones to cancer is limited. Here we study this phenomenon in the context of clonal hematopoiesis (CH) and the development of therapy-related myeloid neoplasms (tM...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Bolton, Kelly L, Ptashkin, Ryan N, Gao, Teng, Braunstein, Lior, Devlin, Sean M, Kelly, Daniel, Patel, Minal, Berthon, Antonin, Syed, Aijazuddin, Yabe, Mariko, Coombs, Catherine C., Caltabellotta, Nicole M., Walsh, Mike, Offit, Kenneth, Stadler, Zsofia, Mandelker, Diana, Schulman, Jessica, Patel, Akshar, Philip, John, Bernard, Elsa, Gundem, Gunes, Ossa, Juan E Arango, Levine, Max, Martinez, Juan S Medina, Farnoud, Noushin, Glodzik, Dominik, Li, Sonya, Robson, Mark E, Lee, Choonsik, Pharoah, Paul D P, Stopsack, Konrad H, Spitzer, Barbara, Mantha, Simon, Fagin, James, Boucai, Laura, Gibson, Christopher J, Ebert, Benjamin L, Young, Andrew L, Druley, Todd, Takahashi, Koichi, Gillis, Nancy, Ball, Markus, Padron, Eric, Hyman, David M, Baselga, Jose, Norton, Larry, Gardos, Stuart, Klimek, Virginia M, Scher, Howard, Bajorin, Dean, Paraiso, Eder, Benayed, Ryma, Arcila, Maria E, Ladanyi, Marc, Solit, David B, Berger, Michael F, Tallman, Martin, Garcia-Closas, Montserrat, Chatterjee, Nilanjan, Diaz, Luis A, Levine, Ross L, Morton, Lindsay M, Zehir, Ahmet, Papaemmanuil, Elli
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7891089/
https://ncbi.nlm.nih.gov/pubmed/33106634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00710-0
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