Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis

Stably acquired mutations in hematopoietic cells represent substrates of selection that may lead to clonal hematopoiesis (CH), a common state in cancer patients that is associated with a heightened risk of leukemia development. Owing to technical and sample size limitations, most CH studies have cha...

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Pubblicato in:Nat Commun
Autori principali: Gao, Teng, Ptashkin, Ryan, Bolton, Kelly L., Sirenko, Maria, Fong, Christopher, Spitzer, Barbara, Menghrajani, Kamal, Ossa, Juan E. Arango, Zhou, Yangyu, Bernard, Elsa, Levine, Max, Martinez, Juan S. Medina, Zhang, Yanming, Franch-Expósito, Sebastià, Patel, Minal, Braunstein, Lior Z., Kelly, Daniel, Yabe, Mariko, Benayed, Ryma, Caltabellotta, Nicole M., Philip, John, Paraiso, Ederlinda, Mantha, Simon, Solit, David B., Diaz, Luis A., Berger, Michael F., Klimek, Virginia, Levine, Ross L., Zehir, Ahmet, Devlin, Sean M., Papaemmanuil, Elli
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804935/
https://ncbi.nlm.nih.gov/pubmed/33436578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20565-7
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