Cancer therapy shapes the fitness landscape of clonal hematopoiesis

Acquired mutations are pervasive across normal tissues. However, our understanding of the processes that drive transformation of certain clones to cancer is limited. Here we study this phenomenon in the context of clonal hematopoiesis (CH) and the development of therapy-related myeloid neoplasms (tM...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Nat Genet
المؤلفون الرئيسيون: Bolton, Kelly L, Ptashkin, Ryan N, Gao, Teng, Braunstein, Lior, Devlin, Sean M, Kelly, Daniel, Patel, Minal, Berthon, Antonin, Syed, Aijazuddin, Yabe, Mariko, Coombs, Catherine C., Caltabellotta, Nicole M., Walsh, Mike, Offit, Kenneth, Stadler, Zsofia, Mandelker, Diana, Schulman, Jessica, Patel, Akshar, Philip, John, Bernard, Elsa, Gundem, Gunes, Ossa, Juan E Arango, Levine, Max, Martinez, Juan S Medina, Farnoud, Noushin, Glodzik, Dominik, Li, Sonya, Robson, Mark E, Lee, Choonsik, Pharoah, Paul D P, Stopsack, Konrad H, Spitzer, Barbara, Mantha, Simon, Fagin, James, Boucai, Laura, Gibson, Christopher J, Ebert, Benjamin L, Young, Andrew L, Druley, Todd, Takahashi, Koichi, Gillis, Nancy, Ball, Markus, Padron, Eric, Hyman, David M, Baselga, Jose, Norton, Larry, Gardos, Stuart, Klimek, Virginia M, Scher, Howard, Bajorin, Dean, Paraiso, Eder, Benayed, Ryma, Arcila, Maria E, Ladanyi, Marc, Solit, David B, Berger, Michael F, Tallman, Martin, Garcia-Closas, Montserrat, Chatterjee, Nilanjan, Diaz, Luis A, Levine, Ross L, Morton, Lindsay M, Zehir, Ahmet, Papaemmanuil, Elli
التنسيق: Artigo
اللغة:Inglês
منشور في: 2020
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7891089/
https://ncbi.nlm.nih.gov/pubmed/33106634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00710-0
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