Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA

IMPORTANCE: Tumor genetic sequencing identifies potentially targetable genetic alterations with therapeutic implications. Analysis has concentrated on detecting tumor-specific variants, but recognition of germline variants may prove valuable as well. OBJECTIVE: To estimate the burden of germline var...

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Опубликовано в: :JAMA Oncol
Главные авторы: Schrader, Kasmintan A., Cheng, Donavan T., Joseph, Vijai, Prasad, Meera, Walsh, Michael, Zehir, Ahmet, Ni, Ai, Thomas, Tinu, Benayed, Ryma, Ashraf, Asad, Lincoln, Annie, Arcila, Maria, Stadler, Zsofia, Solit, David, Hyman, David M., Zhang, Liying, Klimstra, David, Ladanyi, Marc, Offit, Kenneth, Berger, Michael, Robson, Mark
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477989/
https://ncbi.nlm.nih.gov/pubmed/26556299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2015.5208
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