Comprehensive detection of germline variants by MSK-IMPACT, a clinical diagnostic platform for solid tumor molecular oncology and concurrent cancer predisposition testing

BACKGROUND: The growing number of Next Generation Sequencing (NGS) tests is transforming the routine clinical diagnosis of hereditary cancers. Identifying whether a cancer is the result of an underlying disease-causing mutation in a cancer predisposition gene is not only diagnostic for a cancer pred...

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Vydáno v:BMC Med Genomics
Hlavní autoři: Cheng, Donavan T., Prasad, Meera, Chekaluk, Yvonne, Benayed, Ryma, Sadowska, Justyna, Zehir, Ahmet, Syed, Aijazuddin, Wang, Yan Elsa, Somar, Joshua, Li, Yirong, Yelskaya, Zarina, Wong, Donna, Robson, Mark E., Offit, Kenneth, Berger, Michael F., Nafa, Khedoudja, Ladanyi, Marc, Zhang, Liying
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Technical Advance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437632/
https://ncbi.nlm.nih.gov/pubmed/28526081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-017-0271-4
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