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Germline EGFR T790M mutation found in multiple members of a familial cohort

Activating mutations in EGFR are present in a subset of lung cancers, and predict sensitivity to EGFR tyrosine kinase inhibitors (TKIs). Acquisition of EGFR T790M is the most common mechanism of resistance to EGFR TKIs and rarely is seen prior to treatment. Germline EGFR T790M mutations have been re...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Thorac Oncol
Hauptverfasser: Yu, Helena A., Arcila, Maria E., Harlan, Megan, Stadler, Zsofia, Ladanyi, Marc, Berger, Michael F., Robson, Mark, Riely, Gregory J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4412273/
https://ncbi.nlm.nih.gov/pubmed/24736080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0000000000000052
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