Germline EGFR T790M mutation found in multiple members of a familial cohort

Activating mutations in EGFR are present in a subset of lung cancers, and predict sensitivity to EGFR tyrosine kinase inhibitors (TKIs). Acquisition of EGFR T790M is the most common mechanism of resistance to EGFR TKIs and rarely is seen prior to treatment. Germline EGFR T790M mutations have been re...

Full description

Saved in:
Bibliographic Details
Published in:J Thorac Oncol
Main Authors: Yu, Helena A., Arcila, Maria E., Harlan, Megan, Stadler, Zsofia, Ladanyi, Marc, Berger, Michael F., Robson, Mark, Riely, Gregory J.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4412273/
https://ncbi.nlm.nih.gov/pubmed/24736080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0000000000000052
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items