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Germline EGFR T790M mutation found in multiple members of a familial cohort
Activating mutations in EGFR are present in a subset of lung cancers, and predict sensitivity to EGFR tyrosine kinase inhibitors (TKIs). Acquisition of EGFR T790M is the most common mechanism of resistance to EGFR TKIs and rarely is seen prior to treatment. Germline EGFR T790M mutations have been re...
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| Publicado no: | J Thorac Oncol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4412273/ https://ncbi.nlm.nih.gov/pubmed/24736080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0000000000000052 |
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