Poor response to erlotinib in patients with tumors containing baseline EGFR T790M mutations found by routine clinical molecular testing

Eitemau Tebyg

• Germline EGFR T790M mutation found in multiple members of a familial cohort
  gan: Yu, Helena A., et al.
  Cyhoeddwyd: (2014)
• Lessons learned from routine, targeted assessment of liquid biopsies for EGFR T790M resistance mutation in patients with EGFR mutant lung cancers
  gan: Mondaca, Sebastian, et al.
  Cyhoeddwyd: (2019)
• Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR mutant lung cancer: Distinct natural history of patients with tumors harboring the T790M mutation
  gan: Oxnard, Geoffrey R., et al.
  Cyhoeddwyd: (2010)
• The T790M resistance mutation in EGFR is only found in cfDNA from erlotinib-treated NSCLC patients that harbored an activating EGFR mutation before treatment
  gan: Demuth, Christina, et al.
  Cyhoeddwyd: (2018)
• Acquired Resistance of EGFR-Mutant Lung Cancer to a T790M-Specific EGFR Inhibitor: Emergence of a Third Mutation (C797S) in the EGFR Tyrosine Kinase Domain
  gan: Yu, Helena A., et al.
  Cyhoeddwyd: (2015)