Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA

IMPORTANCE: Tumor genetic sequencing identifies potentially targetable genetic alterations with therapeutic implications. Analysis has concentrated on detecting tumor-specific variants, but recognition of germline variants may prove valuable as well. OBJECTIVE: To estimate the burden of germline var...

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Publicado en:JAMA Oncol
Main Authors: Schrader, Kasmintan A., Cheng, Donavan T., Joseph, Vijai, Prasad, Meera, Walsh, Michael, Zehir, Ahmet, Ni, Ai, Thomas, Tinu, Benayed, Ryma, Ashraf, Asad, Lincoln, Annie, Arcila, Maria, Stadler, Zsofia, Solit, David, Hyman, David M., Zhang, Liying, Klimstra, David, Ladanyi, Marc, Offit, Kenneth, Berger, Michael, Robson, Mark
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477989/
https://ncbi.nlm.nih.gov/pubmed/26556299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2015.5208
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