Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA

IMPORTANCE: Tumor genetic sequencing identifies potentially targetable genetic alterations with therapeutic implications. Analysis has concentrated on detecting tumor-specific variants, but recognition of germline variants may prove valuable as well. OBJECTIVE: To estimate the burden of germline var...

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Détails bibliographiques
Publié dans:JAMA Oncol
Auteurs principaux: Schrader, Kasmintan A., Cheng, Donavan T., Joseph, Vijai, Prasad, Meera, Walsh, Michael, Zehir, Ahmet, Ni, Ai, Thomas, Tinu, Benayed, Ryma, Ashraf, Asad, Lincoln, Annie, Arcila, Maria, Stadler, Zsofia, Solit, David, Hyman, David M., Zhang, Liying, Klimstra, David, Ladanyi, Marc, Offit, Kenneth, Berger, Michael, Robson, Mark
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477989/
https://ncbi.nlm.nih.gov/pubmed/26556299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2015.5208
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