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Ultrastructure and pathology of prion protein amyloid accumulation and cellular damage in extraneural tissues of scrapie-infected transgenic mice expressing anchorless prion protein

In most human and animal prion diseases the abnormal disease-associated prion protein (PrPSc) is deposited as non-amyloid aggregates in CNS, spleen and lymphoid organs. In contrast, in humans and transgenic mice with PrP mutations which cause expression of PrP lacking a glycosylphosphatidylinositol...

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發表在:Prion
Main Authors: Race, Brent, Jeffrey, Martin, McGovern, Gillian, Dorward, David, Chesebro, Bruce
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553302/
https://ncbi.nlm.nih.gov/pubmed/28759310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2017.1336274
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