Increased Infectivity of Anchorless Mouse Scrapie Prions in Transgenic Mice Overexpressing Human Prion Protein

Prion protein (PrP) is found in all mammals, mostly as a glycoprotein anchored to the plasma membrane by a C-terminal glycosylphosphatidylinositol (GPI) linkage. Following prion infection, host protease-sensitive prion protein (PrPsen or PrPC) is converted into an abnormal, disease-associated, prote...

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Vydáno v:J Virol
Hlavní autoři: Race, Brent, Phillips, Katie, Meade-White, Kimberly, Striebel, James, Chesebro, Bruce
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Prions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442444/
https://ncbi.nlm.nih.gov/pubmed/25810548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00362-15
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