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Distinct patterns of spread of prion infection in brains of mice expressing anchorless or anchored forms of prion protein
BACKGROUND: In humans and animals, prion protein (PrP) is usually expressed as a glycophosphatidylinositol (GPI)-anchored membrane protein, but anchorless PrP may be pathogenic in humans with certain familial prion diseases. Anchored PrP expressed on neurons mediates spread of prions along axons in...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3904166/ https://ncbi.nlm.nih.gov/pubmed/24447368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-8 |
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