Distinct patterns of spread of prion infection in brains of mice expressing anchorless or anchored forms of prion protein

BACKGROUND: In humans and animals, prion protein (PrP) is usually expressed as a glycophosphatidylinositol (GPI)-anchored membrane protein, but anchorless PrP may be pathogenic in humans with certain familial prion diseases. Anchored PrP expressed on neurons mediates spread of prions along axons in...

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Détails bibliographiques
Auteurs principaux: Rangel, Alejandra, Race, Brent, Phillips, Katie, Striebel, James, Kurtz, Nancy, Chesebro, Bruce
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2014
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904166/
https://ncbi.nlm.nih.gov/pubmed/24447368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-8
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