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Non-amyloid and amyloid prion protein deposits in prion-infected mice differ in blockage of interstitial brain fluid

AIMS: Prion diseases are characterized by brain deposits of misfolded aggregated protease-resistant prion protein (PrP), termed PrPres. In humans and animals, PrPres is found as either disorganized non-amyloid aggregates or organized amyloid fibrils. Both PrPres forms are found in extracellular spac...

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Hlavní autoři: Rangel, Alejandra, Race, Brent, Striebel, James, Chesebro, Bruce
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567241/
https://ncbi.nlm.nih.gov/pubmed/22998478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2990.2012.01303.x
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