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Unusual cerebral vascular prion protein amyloid distribution in scrapie-infected transgenic mice expressing anchorless prion protein

BACKGROUND: In some prion diseases, misfolded aggregated protease-resistant prion protein (PrPres) is found in brain as amyloid, which can cause cerebral amyloid angiopathy. Small diffusible precursors of PrPres amyloid might flow with brain interstitial fluid (ISF), possibly accounting for the peri...

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Detalhes bibliográficos
Main Authors: Rangel, Alejandra, Race, Brent, Klingeborn, Mikael, Striebel, James, Chesebro, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893542/
https://ncbi.nlm.nih.gov/pubmed/24252347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-25
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