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Kinetic Isotope Effects and Transition State Structure for Human Phenylethanolamine N-Methyltransferase

Phenylethanolamine N-methyltransferase (PNMT) catalyzes the S-adenosyl-l-methionine (SAM)-dependent conversion of norepinephrine to epinephrine. Epinephrine has been associated with critical processes in humans including the control of respiration and blood pressure. Additionally, PNMT activity has...

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Publicat a:ACS Chem Biol
Autors principals: Stratton, Christopher F., Poulin, Myles B., Du, Quan, Schramm, Vern L.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553282/
https://ncbi.nlm.nih.gov/pubmed/27997103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00922
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