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The Transition-State Structure for Human MAT2A from Isotope Effects
Human methionine S-adenosyltransferase (MAT2A) catalyzes the formation of S-adenosylmethionine (SAM) from ATP and methionine. Synthetic lethal genetic analysis has identified MAT2A as an anticancer target in tumor cells lacking expression of 5′-methylthioadenosine phosphorylase (MTAP). Approximately...
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| 出版年: | J Am Chem Soc |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5674783/ https://ncbi.nlm.nih.gov/pubmed/28880543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b05803 |
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