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Recycling nicotinamide. The transition-state structure of human nicotinamide phosphoribosyltransferase

Human nicotinamide phosphoribosyltransferase (NAMPT) replenishes the NAD pool and controls the activities of sirtuins (SIRT), mono- and poly-(ADP-ribose) polymerases (PARP) and NAD nucleosidase (CD38). The nature of the enzymatic transition-state (TS) is central to understanding the function of NAMP...

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Autors principals: Burgos, Emmanuel S., Vetticatt, Mathew J., Schramm, Vern L.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627370/
https://ncbi.nlm.nih.gov/pubmed/23373462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja310180c
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