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Recycling nicotinamide. The transition-state structure of human nicotinamide phosphoribosyltransferase
Human nicotinamide phosphoribosyltransferase (NAMPT) replenishes the NAD pool and controls the activities of sirtuins (SIRT), mono- and poly-(ADP-ribose) polymerases (PARP) and NAD nucleosidase (CD38). The nature of the enzymatic transition-state (TS) is central to understanding the function of NAMP...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3627370/ https://ncbi.nlm.nih.gov/pubmed/23373462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja310180c |
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