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Transition State Analysis of Thymidine Hydrolysis by Human Thymidine Phosphorylase
Human thymidine phosphorylase (hTP) is responsible for thymidine (dT) homeostasis and its action promotes angiogenesis. In the absence of phosphate, hTP catalyzes a slow hydrolytic depyrimidination of dT yielding thymine and 2-deoxyribose (dRib). Its transition state was characterized using multiple...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2948953/ https://ncbi.nlm.nih.gov/pubmed/20804144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja105041j |
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