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Transition State Analysis of Thymidine Hydrolysis by Human Thymidine Phosphorylase

Human thymidine phosphorylase (hTP) is responsible for thymidine (dT) homeostasis and its action promotes angiogenesis. In the absence of phosphate, hTP catalyzes a slow hydrolytic depyrimidination of dT yielding thymine and 2-deoxyribose (dRib). Its transition state was characterized using multiple...

詳細記述

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書誌詳細
主要な著者: Schwartz, Phillip A., Vetticatt, Mathew, Schramm, Vern L.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948953/
https://ncbi.nlm.nih.gov/pubmed/20804144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja105041j
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