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DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes
The Runt-related transcription factor 2 (RUNX2) is critical for bone formation as well as chondrocyte maturation. Matrix metalloproteinase (MMP)-13 is a major contributor to cartilage degradation in osteoarthritis (OA). We and others have shown that the abnormal MMP13 gene expression in OA chondrocy...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5552713/ https://ncbi.nlm.nih.gov/pubmed/28798419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08418-8 |
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