DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes

The Runt-related transcription factor 2 (RUNX2) is critical for bone formation as well as chondrocyte maturation. Matrix metalloproteinase (MMP)-13 is a major contributor to cartilage degradation in osteoarthritis (OA). We and others have shown that the abnormal MMP13 gene expression in OA chondrocy...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Takahashi, Atsushi, de Andrés, María C., Hashimoto, Ko, Itoi, Eiji, Otero, Miguel, Goldring, Mary B., Oreffo, Richard O. C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552713/
https://ncbi.nlm.nih.gov/pubmed/28798419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08418-8
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak