DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes

The Runt-related transcription factor 2 (RUNX2) is critical for bone formation as well as chondrocyte maturation. Matrix metalloproteinase (MMP)-13 is a major contributor to cartilage degradation in osteoarthritis (OA). We and others have shown that the abnormal MMP13 gene expression in OA chondrocy...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Takahashi, Atsushi, de Andrés, María C., Hashimoto, Ko, Itoi, Eiji, Otero, Miguel, Goldring, Mary B., Oreffo, Richard O. C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552713/
https://ncbi.nlm.nih.gov/pubmed/28798419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08418-8
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