Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites

The role of DNA methylation in the regulation of catabolic genes such as MMP13 and IL1B, which have sparse CpG islands, is poorly understood in the context of musculoskeletal diseases. We report that demethylation of specific CpG sites at −110 bp and −299 bp of the proximal MMP13 and IL1B promoters,...

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Bibliografiske detaljer
Main Authors: Hashimoto, Ko, Otero, Miguel, Imagawa, Kei, de Andrés, María C., Coico, Jonathan M., Roach, Helmtrud I., Oreffo, Richard O. C., Marcu, Kenneth B., Goldring, Mary B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617244/
https://ncbi.nlm.nih.gov/pubmed/23417678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.421156
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