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Loss of Methylation in CpG Sites in the NF-κB Enhancer Elements of Inducible Nitric Oxide Synthase Is Responsible for Gene Induction in Human Articular Chondrocytes

OBJECTIVE: To investigate whether the abnormal expression of inducible nitric oxide synthase (iNOS) by osteoarthritic (OA) human chondrocytes is associated with changes in the DNA methylation status in the promoter and/or enhancer elements of iNOS. METHODS: Expression of iNOS was quantified by quant...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: de Andrés, María C., Imagawa, Kei, Hashimoto, Ko, Gonzalez, Antonio, Roach, Helmtrud I., Goldring, Mary B., Oreffo, Richard O. C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937961/
https://ncbi.nlm.nih.gov/pubmed/23239081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.37806
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