Association of Reduced Type IX Collagen Gene Expression in Human Osteoarthritic Chondrocytes With Epigenetic Silencing by DNA Hypermethylation

OBJECTIVE: To investigate whether the changes in collagen gene expression in osteoarthritic (OA) human chondrocytes are associated with changes in the DNA methylation status in the COL2A1 enhancer and COL9A1 promoter. METHODS: Expression levels were determined using quantitative reverse transcriptio...

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Bibliographic Details
Main Authors: Imagawa, Kei, de Andrés, María C, Hashimoto, Ko, Itoi, Eiji, Otero, Miguel, Roach, Helmtrud I, Goldring, Mary B, Oreffo, Richard O C
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
Subjects:
Osteoarthritis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211984/
https://ncbi.nlm.nih.gov/pubmed/25048791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38774
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