Association of Reduced Type IX Collagen Gene Expression in Human Osteoarthritic Chondrocytes With Epigenetic Silencing by DNA Hypermethylation

OBJECTIVE: To investigate whether the changes in collagen gene expression in osteoarthritic (OA) human chondrocytes are associated with changes in the DNA methylation status in the COL2A1 enhancer and COL9A1 promoter. METHODS: Expression levels were determined using quantitative reverse transcriptio...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Imagawa, Kei, de Andrés, María C, Hashimoto, Ko, Itoi, Eiji, Otero, Miguel, Roach, Helmtrud I, Goldring, Mary B, Oreffo, Richard O C
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Osteoarthritis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211984/
https://ncbi.nlm.nih.gov/pubmed/25048791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38774
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados