Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation

During obesity, macrophages can infiltrate metabolic tissues, and contribute to chronic low-grade inflammation, and mediate insulin resistance and diabetes. Recent studies have elucidated the metabolic role of JAK2, a key mediator downstream of various cytokines and growth factors. Our study address...

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Publicado no:Sci Rep
Main Authors: Desai, Harsh R., Sivasubramaniyam, Tharini, Revelo, Xavier S., Schroer, Stephanie A., Luk, Cynthia T., Rikkala, Prashanth R., Metherel, Adam H., Dodington, David W., Park, Yoo Jin, Kim, Min Jeong, Rapps, Joshua A., Besla, Rickvinder, Robbins, Clinton S., Wagner, Kay-Uwe, Bazinet, Richard P., Winer, Daniel A., Woo, Minna
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550513/
https://ncbi.nlm.nih.gov/pubmed/28794431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07923-0
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