Dj1 deficiency protects against atherosclerosis with anti-inflammatory response in macrophages

Inflammation is a key contributor to atherosclerosis with macrophages playing a pivotal role through the induction of oxidative stress and cytokine/chemokine secretion. DJ1, an anti-oxidant protein, has shown to paradoxically protect against chronic and acute inflammation. However, the role of DJ1 i...

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Udgivet i:Sci Rep
Main Authors: Sivasubramaniyam, Tharini, Yang, Jiaqi, Cheng, Henry S., Zyla, Alexandra, Li, Angela, Besla, Rickvinder, Dotan, Idit, Revelo, Xavier S., Shi, Sally Yu, Le, Helen, Schroer, Stephanie A., Dodington, David W., Park, Yoo Jin, Kim, Min Jeong, Febbraro, Daniella, Ruel, Isabelle, Genest, Jacques, Kim, Raymond H., Mak, Tak W., Winer, Daniel A., Robbins, Clinton S., Woo, Minna
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907332/
https://ncbi.nlm.nih.gov/pubmed/33633277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84063-6
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