FAK signalling controls insulin sensitivity through regulation of adipocyte survival

Focal adhesion kinase (FAK) plays a central role in integrin signalling, which regulates growth and survival of tumours. Here we show that FAK protein levels are increased in adipose tissue of insulin-resistant obese mice and humans. Disruption of adipocyte FAK in mice or in 3T3 L1 cells decreases a...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Luk, Cynthia T., Shi, Sally Yu, Cai, Erica P., Sivasubramaniyam, Tharini, Krishnamurthy, Mansa, Brunt, Jara J., Schroer, Stephanie A., Winer, Daniel A., Woo, Minna
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5303880/
https://ncbi.nlm.nih.gov/pubmed/28165007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14360
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