Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells

Most platelet membrane proteins are modified by mucin-type core 1-derived glycans (O-glycans). However, the biological importance of O-glycans in platelet clearance is unclear. Here, we generated mice with a hematopoietic cell-specific loss of O-glycans (HC C1galt1(−/−)). These mice lack O-glycans o...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Li, Yun, Fu, Jianxin, Ling, Yun, Yago, Tadayuki, McDaniel, J. Michael, Song, Jianhua, Bai, Xia, Kondo, Yuji, Qin, Yannan, Hoover, Christopher, McGee, Samuel, Shao, Bojing, Liu, Zhenghui, Sonon, Roberto, Azadi, Parastoo, Marth, Jamey D., McEver, Rodger P., Ruan, Changgeng, Xia, Lijun
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547648/
https://ncbi.nlm.nih.gov/pubmed/28716912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707662114
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