Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells

Most platelet membrane proteins are modified by mucin-type core 1-derived glycans (O-glycans). However, the biological importance of O-glycans in platelet clearance is unclear. Here, we generated mice with a hematopoietic cell-specific loss of O-glycans (HC C1galt1(−/−)). These mice lack O-glycans o...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Li, Yun, Fu, Jianxin, Ling, Yun, Yago, Tadayuki, McDaniel, J. Michael, Song, Jianhua, Bai, Xia, Kondo, Yuji, Qin, Yannan, Hoover, Christopher, McGee, Samuel, Shao, Bojing, Liu, Zhenghui, Sonon, Roberto, Azadi, Parastoo, Marth, Jamey D., McEver, Rodger P., Ruan, Changgeng, Xia, Lijun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547648/
https://ncbi.nlm.nih.gov/pubmed/28716912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707662114
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados